AOD9604 is a synthetic peptide composed of 16 amino acids. It corresponds to residues 177 through 191 of its parent sequence, with a tyrosine residue at the N-terminus in place of the phenylalanine found at position 176. Its molecular formula is C₇₈H₁₂₃N₂₃O₂₃S₂, its molecular weight is 1,815.1 g/mol, and its CAS number is 221231-10-3. The peptide contains an intramolecular disulfide bridge between two cysteine residues, which constrains its three-dimensional structure.

Because tyrosine differs from phenylalanine by a single hydroxyl group, AOD9604 and the unmodified 176-191 sequence are both 16-residue peptides that differ by exactly one oxygen atom — 1,815.1 g/mol versus 1,799.1 g/mol. That difference is not resolvable by HPLC purity analysis alone; mass-spectrometric identity confirmation is required to establish which of the two compounds is present in a given sample. AOD9604 was first synthesized in the 1990s and is supplied as a white to off-white lyophilized (freeze-dried) powder that is readily soluble in water.

This product is strictly for research purposes only. Not approved for human or animal use.

PubChem Reference: View compound profile on NIH PubChem