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SLU-PP-332

SLU-PP-332

Price range: $50.00 through $75.00

SLU-PP-332 is a synthetic small molecule, not a peptide: an acylhydrazone formed from naphthalene-2-carbaldehyde and 4-hydroxybenzohydrazide, with the systematic name (E)-4-hydroxy-N′-(naphthalen-2-ylmethylene)benzohydrazide. It has the molecular formula C18H14N2O2, a molecular weight of 290.32 g/mol and CAS number 303760-60-3. First characterized at Saint Louis University, it is described in the primary literature as a pan-agonist of the estrogen-related receptors ERRα, ERRβ and ERRγ, with the highest reported potency at ERRα. The planar naphthalene–phenol scaffold makes it poorly water-soluble; it dissolves in DMSO. Supplied as a solid powder in 5mg and 10mg vials, stored frozen at −20 °C and protected from light. This product is strictly for research purposes only.

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Proudly Made in the USA
USA manufactured · USA tested · Ships from Gilbert, AZ
USA Manufactured
USA Lab Tested
Ships from Gilbert, AZ

Overview

SLU-PP-332 is a synthetic small molecule — not a peptide — with the molecular formula C18H14N2O2, a molecular weight of approximately 290.32 g/mol and CAS number 303760-60-3. Structurally it is an acylhydrazone: naphthalene-2-carbaldehyde condensed with 4-hydroxybenzohydrazide, giving (E)-4-hydroxy-N′-(naphthalen-2-ylmethylene)benzohydrazide. The compound existed in commercial screening libraries for years before it was identified and characterized by the Burris laboratory at Saint Louis University, from which it takes its name.

In the primary literature (Billon et al., ACS Chemical Biology, 2023) SLU-PP-332 is reported as a pan-agonist of the three estrogen-related receptors ERRα, ERRβ and ERRγ — orphan nuclear receptors involved in mitochondrial gene expression — with the highest reported potency at ERRα. The reported findings come from cultured cell lines and rodent skeletal muscle. Two handling notes follow from the chemistry: acylhydrazones can hydrolyze in aqueous acid and photoisomerize, so the powder should be kept frozen and protected from light, and the flat aromatic scaffold makes it poorly soluble in water, with DMSO the reported solvent. It is supplied as a solid powder in 5mg and 10mg vials.

This product is strictly for research purposes only. Not approved for human or animal use.

PubChem Reference: View compound profile on NIH PubChem

This product is strictly for research purposes only. Not approved for human or animal use.

Key Characteristics

MOLECULAR PROFILE

Formula: C18H14N2O2

Weight: 290.32 g/mol

CAS: 303760-60-3

PubChem CID: 5338394

Structure: Acylhydrazone small molecule (naphthalene / 4-hydroxybenzohydrazide)

Target: ERRα, ERRβ, ERRγ (pan-ERR agonist)

PHYSICAL PROPERTIES

Form: Solid powder (appearance per batch COA)

Solubility: Soluble in DMSO; poorly soluble in water

Purity: ≥98% (HPLC)

Storage: Keep frozen −4 °F (−20 °C), protect from light

Weight 0.08 lbs
Dimensions 0.87 × 1.18 × 0.87 in
Size

5mg, 10mg
SKU: OATH-SLU-PP-332 Categories: , Tag:
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